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Journal of Thoracic Oncology : Official... Oct 2011Carcinoma in situ at the mucosal bronchial resection margin is a rarely reported event. At present, such histological findings at the resection margins are classified as... (Review)
Review
Carcinoma in situ at the mucosal bronchial resection margin is a rarely reported event. At present, such histological findings at the resection margins are classified as R1(is), thus representing an incomplete resection. A review of the English literature on the topic was undertaken to try to better define the significance of such findings and to define possible areas of prospective data acquisition to further define the problem and its management.
Topics: Bronchial Neoplasms; Carcinoma in Situ; Humans
PubMed: 21918388
DOI: 10.1097/JTO.0b013e31822ae082 -
Head and Neck Pathology Dec 2017Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old...
Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old man who presented with a 2.5 cm lung mass that was partially obstructing the right bronchus intermedius. The tumor consisted of cords and nests of clear and eosinophilic cells in a hyalinized stromal background. The neoplastic cells expressed cytokeratin (CK) 7, CK 5/6, high-molecular weight cytokeratin (34BE12), p63 and p40, while TTF-1, napsin A, CK20, S100, smooth muscle actin, synaptophysin and chromogranin were negative. Mucicarmine stain also was negative in the lesional cells. Fluorescence in situ hybridization using break apart probes revealed rearrangement of the Ewing Sarcoma Breakpoint Region 1 gene locus. The morphologic, immunophenotypic and cytogenetic findings confirmed the diagnosis of HCCC, most likely of bronchial submucosal gland origin. To our knowledge, only two other reports of primary pulmonary HCCC are available in English literature.
Topics: Adenocarcinoma, Clear Cell; Bronchial Neoplasms; Humans; Male; Middle Aged
PubMed: 28508996
DOI: 10.1007/s12105-017-0820-3 -
JSLS : Journal of the Society of... 1997A lung carcinoma with tumor involving more than one lobe or in close proximity to the mainstem bronchus often requires pneumonectomy for surgical cure. Inflammation,...
A lung carcinoma with tumor involving more than one lobe or in close proximity to the mainstem bronchus often requires pneumonectomy for surgical cure. Inflammation, bulky tumors, and dense adhesions limit the operative field of vision and may result in the abandonment of procedures with potential for complete extirpation. This case illustrates the utility of thoracoscopy in visualization of the hilum and other neurovascular structures in a patient with a proximal tumor and dense intrathoracic adhesions. Successful resection was made possible by use of combined open and thoracoscopic modalities.
Topics: Biopsy, Needle; Bronchial Neoplasms; Carcinoma, Squamous Cell; Humans; Male; Middle Aged; Pneumonectomy; Thoracoscopy; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 9876652
DOI: No ID Found -
Chinese Clinical Oncology Apr 2020Endobronchial lipomas (ELs) are extremely rare benign tumors that account for 0.1-0.4% of all bronchial tumors. Our study aims to better characterize these lesions based... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Endobronchial lipomas (ELs) are extremely rare benign tumors that account for 0.1-0.4% of all bronchial tumors. Our study aims to better characterize these lesions based on their baseline demographic characteristics, size, location, association with smoking and establish a treatment modality of choice for such tumors.
METHODS
We conducted a retrospective meta-analysis of 29 studies of EL reported from 1994 till present. These 29 studies yielded 36 patient encounters which were included in our study. Categorical outcomes were compared between study groups using chi-square test. P value <0.05 was considered statistically significant.
RESULTS
Our study has shown that smaller lesions more likely to be ELs or benign lung tumors. Eighty percent of ELs had a size <1.5 cm (P=0.056) and the other tumor types had a size ≥1.5 cm.
CONCLUSIONS
These tumors are difficult to diagnose due to their nonspecific presenting complaints unless pulmonologists maintain a high index of suspicion. Treatment options such surgical resection (SR) or bronchoscopic resection (BR) are available and interventions should be planned on a case-by-case basis by a multidisciplinary team.
Topics: Adult; Bronchial Neoplasms; Female; Humans; Lipoma; Male; Retrospective Studies
PubMed: 31594363
DOI: 10.21037/cco.2019.08.17 -
The Pan African Medical Journal Aug 2010
Topics: Aged; Biopsy; Bronchial Neoplasms; Bronchoscopy; Combined Modality Therapy; Contrast Media; Diagnosis, Differential; Humans; Male; Melanoma; Neoplasm Staging; Skin Neoplasms; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 21436950
DOI: No ID Found -
Internal Medicine (Tokyo, Japan) Jan 2001We describe a case of solitary papilloma of the bronchus and provide a review of 38 similar cases reported in Japan. A 70-year-old man complained of cough and sputum.... (Review)
Review
We describe a case of solitary papilloma of the bronchus and provide a review of 38 similar cases reported in Japan. A 70-year-old man complained of cough and sputum. Chest X-rays and CT scans revealed atelectasis of the right middle lobe. On bronchoscopy, a polypoid tumor was found at the orifice of the bronchus of the right middle lobe. The tumor was histologically diagnosed as a squamous papilloma with moderate atypia. Because of elevated tumor markers and the reported high incidence of malignant changes in papillomas, the tumor was endoscopically resected by electrosurgical snare. While this procedure resulted in improvement of atelectasis, the chest CT taken subsequently revealed a mass adjacent to the resected polypoid tumor in the middle lobe bronchus. Percutaneous needle biopsy followed by histopathological examination confirmed the tumor to be a squamous cell carcinoma. Only three cases of malignant changes in papillomas have been previously reported in Japan. Electrosurgical snare, which allows the identification of tissue at the tumor base, should be the treatment of choice rather than YAG laser surgery.
Topics: Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy, Needle; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Contraindications; Disease Progression; Electrosurgery; Humans; Keratins; Male; Mitomycin; Neoplasm Proteins; Papilloma; Parkinson Disease, Secondary; Pneumonectomy; Pulmonary Atelectasis; Serpins; Tomography, X-Ray Computed; Vindesine
PubMed: 11201373
DOI: 10.2169/internalmedicine.40.56 -
BMC Pulmonary Medicine Feb 2019Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is... (Review)
Review
BACKGROUND
Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare.
CASE PRESENTATION
We treated a 45-year-old female who presented with recurrent pneumonia. Chest X-ray showed a consolidation in the left upper lobe. The patient was treated with various courses of antibiotics without full recovery after six months. Computed tomography (CT) scan demonstrated a central mass in the left upper lobe. Bronchoscopy revealed an endobronchial, well-defined lesion that totally obstructed the left upper lobe bronchus. Bronchial biopsy showed typical carcinoid tumor. Rigid bronchoscopy with electrocautery was attempted, but we were unable to radically remove the tumor. Therefore lobectomy was performed. The surgical pathology specimen showed atypical bronchial carcinoid and consolidations in the lung parenchyma with granulomatous inflammation distally of the bronchial obstruction. Ziehl-Neelsen staining demonstrated acid fast bacilli indicative of mycobacterial infection.
CONCLUSIONS
This case history illustrates the importance of careful surgical pathologic examination, not only of the resected tumor, but also of the postobstructive lung parenchyma. Specific postobstructive infections such as tuberculosis or nontuberculous mycobacteria (NTM) can have clinical implications.
Topics: Airway Obstruction; Biopsy; Bronchial Neoplasms; Bronchoscopy; Carcinoid Tumor; Female; Humans; Lung; Middle Aged; Mycobacterium; Mycobacterium Infections; Pneumonectomy; Pneumonia, Bacterial; Tomography, X-Ray Computed
PubMed: 30767776
DOI: 10.1186/s12890-019-0806-x -
International Journal of Surgery... Sep 2016Carcinoids are tumors that originate from diffuse neuroendocrine system cells (APUD cells) and represent 1-2% of all pulmonary tumors. Although surgical resection...
Carcinoids are tumors that originate from diffuse neuroendocrine system cells (APUD cells) and represent 1-2% of all pulmonary tumors. Although surgical resection remains the mainstay of treatment, bronchoscopic radical resection of typical carcinoids in selected cases exhibiting endoluminal growth and small implant base has also been explored. Bronchoscopic removal of endobronchial lesions may also reduce the risk of post-obstructive infections and improve pulmonary function, allowing the patient to undergo surgery in better clinical and respiratory state. In this paper we have evaluated the impact on surgical planning and outcome of preoperative bronchoscopic resection in treatment of endobronchial typical carcinoids. Our observations further support the role of bronchoscopic treatment before surgery in endobronchial typical carcinoids.
Topics: Adolescent; Adult; Aged; Bronchial Neoplasms; Bronchoscopy; Carcinoid Tumor; Female; Humans; Male; Middle Aged; Pneumonectomy; Preoperative Care; Tomography, X-Ray Computed
PubMed: 27255131
DOI: 10.1016/j.ijsu.2016.05.054 -
Annals of the Royal College of Surgeons... Jan 2017Paragangliomas are rare lung tumours; endobronchial localisation is even more rare. This report describes the case of a 59-year-old patient with a symptomatic...
Paragangliomas are rare lung tumours; endobronchial localisation is even more rare. This report describes the case of a 59-year-old patient with a symptomatic endobronchial paraganglioma successfully resected by means of pulmonary lobectomy. Recognition of this uncommon tumour can lead to a correct diagnosis and therapeutic strategy.
Topics: Bronchial Neoplasms; Bronchoscopy; Female; Humans; Middle Aged; Multimodal Imaging; Paraganglioma; Tomography, Emission-Computed; Tomography, X-Ray Computed
PubMed: 27659380
DOI: 10.1308/rcsann.2016.0284 -
Journal of Cardiothoracic Surgery Jun 2010To report our experience for the treatment of lung tumors of the right main bronchus (RMB) invading the carina. (Review)
Review
BACKGROUND
To report our experience for the treatment of lung tumors of the right main bronchus (RMB) invading the carina.
METHODS
From February 2000 till January 2007 we have identified 8 cases (1.09%) requiring carinal surgery.Plan of action: Close cooperation with anaesthetics, long flexible ET tube, Right posterolateral thoracotomy, no irrevocable steps until resection guaranteed, mobilization of trachea and main bronchus, division of the trachea & Left main bronchus. Intubate across surgical field. Tailoring for airway size discrepancies, appropriately. Construction of the tracheobronchial anastomosis around the ventilatory tube. Skillfull reintubation, over a long boogie.
RESULTS
Mortality: 12.5% due to ARDS (one patient)Morbidity: anastomotic stenosis requiring stent (one patient). Follow-up 52 +/- 11 months.Recurrences: 2 patients (both with pathological N2 disease on histology).
CONCLUSIONS
Success of carinal surgery depends on careful patient selection, team approach and attention to detail. Patients with N2 disease carry the worst prognosis.
Topics: Aged; Algorithms; Bronchi; Bronchial Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pneumonectomy; Thoracotomy; Trachea
PubMed: 20565903
DOI: 10.1186/1749-8090-5-51